Ras inhibitors affects kidney vessels to greater extent

Hypertension treatment is resulting in blood flow obstruction, focal ischemia, and fibrosis in kidney vessels. Study  conducted on rats said that renin cells are responsible for vascular disease. Given these findings, prospective morphological studies in humans are necessary to determine the extent of renal vascular damage caused by the widespread use of inhibitors of the Renin Angiostensin System.

Hypertension is severe disease with dire consequences known to be a major risk factor for cardiovascular disease, stroke, end-stage renal disease, and death. Vascular hypertrophy with attendant organ injury is a serious disorder usually associated with severe, chronic hypertension. Deletion of renin or inhibition of the RAS leads to concentric thickening of the intrarenal arteries and arterioles reveals a study in rats published in the Journal of Clinical Investigation Insight.