Blood Test Validated for Early Alzheimer's Detection in Asian Populations: New Study Shows
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A study in Alzheimer's & Dementia, a leading journal in dementia research, has demonstrated the high accuracy of plasma p-tau217 as a blood-based biomarker for detecting abnormal brain beta-amyloid (Aβ) pathology, a hallmark of Alzheimer’s disease (AD). More significantly, the study validates its effectiveness even in individuals with cerebrovascular disease (CeVD), which is highly prevalent in Asian populations. This finding can enhance early diagnosis, improve patient risk stratification, and facilitate better clinical management of AD in diverse populations.
Brain amyloid status on amyloid PET scans was assessed along with the plasma ALZpath p-tau217 assay to derive three-range reference points for PET Aβ+ based on 90% sensitivity (lower threshold) and 90% specificity (upper threshold).
The results showed that plasma p-tau217 outperformed routine clinical assessments and other plasma biomarkers. The high-risk group showed significantly higher rates of cognitive decline than the low-risk group.
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