Breakthrough in Spinal Cord Injury Treatment offers hope for Paralysis patients

Using projection-specific and comparative single-nucleus RNA sequencing techniques, scientists identified the neuronal subpopulations responsible for restoring walking ability following incomplete SCI. The study showed that coaxing the transected axons of these neurons to their natural target regions through chemical attraction and guidance led to significant improvements in walking function after complete SCI in mice. In contrast, regenerating axons across the lesion without such guidance had no substantial effect.

This discovery holds immense promise for individuals who have suffered from spinal cord injuries, which often result in life-altering consequences, including paralysis. The findings suggest that merely stimulating axon regrowth may not be sufficient; it is equally crucial to ensure that these regenerated axons reach their intended destinations in the spinal cord.

Reference: SCIENCE, 21 Sep 2023, Vol 381, Issue 6664, pp. 1338-1345

DOI: 10.1126/science.adi6412