Can Midlife Estrogen Therapy Reduce Dementia Risk, Study Finds

The researchers believe that estrogen therapy may help to protect against dementia by reducing inflammation and improving blood flow to the brain. They also note that estrogen therapy may help to reduce the accumulation of amyloid plaques and tau tangles, which are two of the hallmarks of Alzheimer's disease.

The findings of this study are important because they suggest that estrogen therapy may be a way to prevent dementia in women. However, the researchers caution that more research is needed to confirm the findings and to determine the optimal timing and dosage of estrogen therapy for dementia prevention.

Ref: Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer’s disease and dementia Matilde Nerattini et al, Volume 15 - 2023 | https://doi.org/10.3389/fnagi.2023.1260427