Exercise training improves obesity-related dementia
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Obesity is a major risk factor for cardiovascular metabolic diseases and neurodegenerative diseases such as dementia. Long-term exercise improves memory and spatial cognition, reduces age-related cognitive decline, and maintains brain volume, but the mechanisms are not fully understood.
Recently, a study from Febbraio lab at Monash University reported that voluntary exercise training (VET) improves long-term memory in high-fat diet (HFD)-induced obese mice, increases hippocampal neurogenesis and the expression of the neurotrophic factor BDNF in the hippocampus, and decreases the expression of the inflammatory factor TNF, suggesting that long-term physical activity can prevent obesity-induced cognitive decline.
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