Glitazones linked to 22% reduced dementia risk: Study
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-10-15 03:30 GMT | Update On 2022-10-15 03:30 GMT
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Use of an older class of type 2 diabetes drugs called glitazones, also known as thiazolidinediones or TZDs for short, is linked to a 22% reduced risk of dementia, reveals a long term study published in the open access journal BMJ Open Diabetes Research and Care.
Because type 2 diabetes and dementia share some of the same physiological patterns, researchers have started to look at whether diabetes drugs might also help stave off or treat dementia. But to date, the findings have been inconsistent.
For the study the researchers compared dementia risk in older people with type 2 diabetes and treated with either a sulfonylurea or a thiazolidinedione (TZD) with those treated with metformin alone. They drew on the electronic health records of 559,106 people diagnosed with type 2 diabetes from the national Veteran Affairs (VA) Health System, spanning the period from January 2000 to December 2019.
Only older patients (aged at least 60) and given a first prescription of metformin, or a sulfonylurea (tolbutamide, glimepiride, glipizide, or glyburide), or a TZD (rosiglitazone or pioglitazone) between January 2001 and December 2017 were included (559,106) in the study. Their health was tracked for an average of nearly 8 years.
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