Journal Club - Dopamine role in social cognition and recognizing emotions

In a study by Schuster et al., healthy participants took haloperidol — a dopamine receptor inhibitor — on one day and a placebo pill on another before completing an emotion recognition task.

They assessed videos of people expressing an emotion through their posture and gait (thatis, slow movements for sadness, quick, jerky movements for anger). The researchers also indirectly measured each person's baseline dopamine levels by testing their working memory.

The effects of haloperidol varied in each person depending on their baseline dopamine levels. In people with low dopamine, the drug increased their ability to recognize emotions, while in people with high dopamine, the drug impaired their ability. Future work will examine how changes in dopamine levels in disorders like Parkinson's disease contribute to social cognition impairments.