Parkinson's disease modeling by Aged neurons from skin
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-09-23 05:30 GMT | Update On 2023-10-17 10:50 GMT
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According to a recent report from Janelle Drouin-Ouellet, Malin Parmar and colleagues in the one way of preserving the aged characteristics of neurons is to make them directly from the patient's skin, without an iPSC intermediate. The researchers succeeded in turning skin cells from Parkinson's disease (PD) patients into so-called dopaminergic (DA) neurons, which are the type of neurons progressively lost in PD, by introducing a specific combination of neural- inducing genes into the skin cells.
In contrast to the PD cells generated from iPS cells, this process of generating DA neurons directly from the skin cells preserved the aged genetic, epigenetic, and metabolic characteristics of the donor age. When compared to aged DA neurons from healthy skin donors, neurons from PD patients featured PD-specific cellular defects, which now could be modelled for the first time from sporadic PD patients which lack a known genetic mutation.
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