Pilot Study Suggests Promising Treatment for Cognitive Improvement in Alzheimer's Risk Group
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A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), which remove old (senescent) cells from the body, suggests that intermittent treatment may hold promise for improving cognitive function in older adults at risk of Alzheimer’s disease.
Published in the eBioMedicine journal, the research explored the effects of DQ on cognition and mobility in individuals with mild cognitive impairment (MCI) and slow gait, which are conditions linked to increased risk of Alzheimer’s disease.
Over 12 weeks, 12 participants took a combination of Dasatinib (100mg) and Quercetin (1250mg) for two days every two weeks. Researchers observed a statistically significant increase of 2.0 points in the Montreal Cognitive Assessment (MoCA) scores in participants with the lowest baseline scores, hinting at potential cognitive benefits. Additionally, reductions in the inflammatory chemical called tumor necrosis factor alpha (TNF-α) correlated with cognitive improvements, suggesting that senolytics might enhance cognitive function by reducing inflammation.
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