Potential markers for alzheimer's disease: Plasma p-tau181/Aβ1-42
Alzheimer's disease is thought to be caused by the abnormal build-up of proteins in and around brain cells. One of the proteins involved is called amyloid, deposits of which form plaques around brain cells. The other protein is called tau, deposits of which form tangles within brain cells. Tau proteins presence is considered to be a classic marker for detecting Alzheimers disease. In...
Alzheimer's disease is thought to be caused by the abnormal build-up of proteins in and around brain cells. One of the proteins involved is called amyloid, deposits of which form plaques around brain cells. The other protein is called tau, deposits of which form tangles within brain cells. Tau proteins presence is considered to be a classic marker for detecting Alzheimers disease.
In Alzheimer's disease, plasma Aβ1-42 and p-tau predict high amyloid status from Aβ-PET and is proving to be the be potential markers. A recent study in MedRxiv by Christopher Fowler and team found that Plasma p-tau181/Aβ1-42 ratio is a potential predictor of both Aβ-PET status and cognitive decline, demonstrating potential as both a diagnostic aid and as a screening and prognostic assay for preclinical Alzheimer's disease trials.
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