Study Examines If Cancer Drugs Can Transform Alzheimer's Care
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The study published in the journal Science proposes that inhibiting the kynurenine pathway-a key regulator of brain metabolism-could enhance or even restore cognitive function in Alzheimer’s disease by restoring normal brain metabolism.
Neuroscientists believe that Alzheimer’s disease might damage brain function by interfering with glucose metabolism, which is essential for maintaining a healthy brain. Essentially, reduced metabolism deprives the brain of the energy it needs, leading to problems with thinking and memory.
A team of neuroscientists has focused on the kynurenine pathway, a key regulator of brain metabolism. They suspect that this pathway is overactivated due to the buildup of amyloid plaques and tau proteins in the brains of Alzheimer’s patients. Researchers have demonstrated that blocking the kynurenine pathway in lab mice with Alzheimer’s Disease can enhance or even restore cognitive function by reestablishing normal brain metabolism.
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