Study Shares New Insights into Alzheimer's Disease
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The team of investigators, led by Professor Ben Goult at the University of Liverpool, have examined the role of two proteins found in the brain and suggest the stability of their relationship to one another is crucial for memory formation and maintenance.
The new study represents a significant step forward in scientists' understanding of Alzheimer's disease. Researchers have shed light on how mechanical signalling in the brain is disrupted and could lead to the condition which accounts for 60-80% of dementia cases worldwide. Disruptions in this mechanical signalling pathway could lead to the disease.
The study proposes that Amyloid Precursor Protein (APP), known for its role in the formation of the amyloid plaques in the brain, that are a characteristic feature in Alzheimer's disease (AD), directly interacts with talin, a synaptic scaffold protein.
The study suggested the talin- Amyloid Precursor Protein interaction is crucial for the mechanical integrity of synapses in the brain and that the misprocessing of Amyloid Precursor Protein observed in Alzheimer's, disrupts mechanical signalling pathways, leading to synaptic degeneration and memory loss, thereby contributing to the progression of Alzheimer's disease. The paper further shows that if talin is removed from cells in culture then the processing of Amyloid Precursor Protein is dramatically altered.
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