Use of inhaled beta-2 agonists not linked to a reduced risk of Parkinson's disease.
Beta-2 agonists are bronchodilators commonly used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Although beta-2 agonists have been associated with a reduced risk of Parkinson’s disease in some previous epidemiological studies, this association was not found in a recent register-based study from the University of Eastern Finland.
Accumulation of the alpha-synuclein protein in the brain plays a central role in Parkinson’s disease. Beta-2 agonists were found to decrease the expression of alpha-synuclein gene in animal and cell models, which could be beneficial in terms of Parkinson’s disease. Furthermore, despite beta-2 agonists having been associated with a reduced risk of Parkinson’s disease in some earlier epidemiological studies, confounding factors such as smoking may have influenced this association.
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