Comparing vaginal progesterone to intramuscular progesterone in embryo transfer.

Progesterone is used to prevent miscarriage in women. Recent studies suggests that progesterone in oil (PIO) is superior to vaginal progesterone (VP;Prometrium) for endometrial preparation in frozen embryo transfer cycles (FET), improving the live birth rate and reducing the rate of miscarriage. PIO has disadvantages including cost, pain, and stress of administration.

Comparing vaginal progesterone to intramuscular progesterone in embryo transfer Journal of Obstetrics and Gynaecology Canada, 2022 Miscarriage is a leading cause of distress among women.

A recent study in the Journal of Obstetrics and Gynaecology Canada says that In their single-centre experience, vaginal progesterone was non-inferior to progesterone in oil for endometrial preparation in frozen embryo transfer cycles.