Intrahepatic cholestasis of pregnancy, to affect infantile food allergy

Intrahepatic cholestasis is a common liver disorder that occurs in pregnant women. There has been a higher incidence of adverse pregnancy outcomes because of this condition. Previous studies mainly focused on the effects of intrahepatic cholestasis of pregnancy on pregnant mothers and fetuses, and few studies reported the postpartum growth and development of fetuses in pregnant women with intrahepatic cholestasis of pregnancy.

A retrospective longitudinal cohort investigation published in European Journal of Obstetrics & Gynecology and Reproductive Biology reported that among 751 pregnant women with intrahepatic cholestasis of pregnancy at 30-32 weeks of gestation that, the average maternal serum total bile acid level was 35.09±30.02 μmol/L, with 58.8% of mothers suffering from mild intrahepatic cholestasis of pregnancy and 29.2% suffering from severe intrahepatic cholestasis of pregnancy. Positive correlations were found between maternal serum total bile acid levels and twin pregnancy showed beta-value of 11.55, and meconium stained amniotic fluid beta-value of 14.64, In addition, the infants of mothers with severe intrahepatic cholestasis of pregnancy were more likely to be allergic to foods at 6 months.