Meta-analysis Finds Significant Reduction in Insulin Resistance with Hormone Therapy

“Our analysis showed that both types of hormone therapy, including oral and transdermal routes, significantly reduced insulin resistance in healthy postmenopausal women, although estrogen alone was associated with a more prominent reduction when compared to a combination hormone therapy,” says Dr. Xuezhi (Daniel) Jiang, lead researcher from Reading Hospital Tower Health and Drexel University College of Medicine in Pennsylvania.

“Hormone therapy is an effective treatment for many bothersome menopause symptoms, including hot flashes,” says Dr. Stephanie Faubion, medical director for The Menopause Society. “This new metaanalysis is important as declining estrogen levels in menopausal women put them at greater risk for insulin resistance and hormone therapy could be beneficial in reducing insulin resistance in these women.”

Reference: “Effect of hormone therapy on insulin resistance in healthy postmenopausal women: A systematic review and meta-analysis of randomized placebo-controlled trials.” presented at 2024 Annual Meeting of The Menopause Society in Chicago September 10-14.