Researchers Produce Viable, Embryo Forming Egg Cells from Underdeveloped Oocytes
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Mature egg cells, or oocytes, are essential for fertilization in assisted reproductive technologies. However, some 'denuded' oocytes, or those lacking the protective granulosa cell layer, fail to mature. Now, in a new study by researchers at Shinshu University, the team has developed a method to culture mature oocytes from these denuded oocytes in the lab.
The study published online in Biology of Reproduction, Assistant Professor Kanako Morohaku and her team at Shinshu University have identified a novel method to produce viable, embryo-forming eggs from denuded oocytes taken from “preantral” follicles in mice.
The researchers isolated denuded oocytes and granulosa cells from mice, which were then grown together in a U-shaped lab dish for eight days. This led to the formation of granulosa cell-oocyte complexes, which allowed the oocytes to interact with supporting cells again. These oocytes were cultured with granulosa cells under high (20%) and low (5%) concentrations of oxygen to observe the difference in oocyte growth.
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