Early Pancreatic Cancer Staging Found Inaccurate 80% of the Time: Finds JAMA Study
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Staging of patients with early pancreatic cancer is inaccurate as much as 80% of the time, according to a new study published in the peer-reviewed journal JAMA. The finding underscores the urgent need for advancements in diagnostic technology and staging, which could significantly alter early pancreatic cancer treatment and research.
In this study, investigators looked at data from more than 48,000 patients in the National Cancer Database. Based on preoperative imaging, all of the patients in the study had either stage 1 or stage 2 pancreatic cancer.
Following surgery to remove their tumours, more than 78% of stage 1 patients and more than 29% of stage 2 patients were upstaged generally to a stage that includes lymph node involvement.
“Our research reveals that staging essential for making treatment decisions and determining research eligibility is often inaccurate in early-stage pancreatic cancer,” said Srinivas Gaddam, MD, associate director of Pancreatic Biliary Research at Cedars-Sinai and senior author of the study. “As the field is racing toward earlier diagnosis, early staging will become increasingly important.”
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