KAIST Researchers Unveil Method to Revert Cancer Cells to Normal Colon Cells
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A research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering has developed a technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.
The research team focused on the observation that during the oncogenesis process, normal cells regress along their differentiation trajectory.
Building on this insight, they developed a technology to create a digital twin of the gene network associated with the differentiation trajectory of normal cells.
Through simulation analysis, the team systematically identified master molecular switches that induce normal cell differentiation.
When these switches were applied to colon cancer cells, the cancer cells reverted to a normal-like state, a result confirmed through molecular and cellular experiments as well as animal studies.
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