Most-accurate tools to research deadliest blood cancer created

AML is a fast-growing cancer with only a 29 percent survival rate. It has often already spread widely in the bone marrow and blood by the time it's first discovered in a patient, so being able to study the cancer, it's progression, and its response to drugs in accurate and viable cell lines is crucial.

Tisch Cancer Center scientists have developed unique models of the deadliest blood cancer, acute myeloid leukemia (AML), creating a transformative resource to study this cancer and eventually its drug response and drug resistance. The models were described in a late-breaking abstract at the annual meeting of the American Association of Cancer Research and simultaneously published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.

These are the first powerful models that are nearly identical to AML found in patients. The researchers said these models represent the disease accurately in genetic composition and in disease characteristics found in laboratory cell cultures, animal models, and patients.

“We show that these models are nearly identical to the leukemias of the patients that they came from and thus are faithful models for acute myeloid leukemia,” said senior author Eirini Papapetrou, MD, PhD, Professor of Oncological Sciences, and Medicine (Hematology and Medical Oncology), at The Tisch Cancer Institute, part of the Tisch Cancer Center, and Director of the Center for Advancement of Blood Cancer Therapies (CABCT) at the Institute for Regenerative Medicine at the Icahn School of Medicine at Mount Sinai. “Animal models do not provide accurate genetic models of AML, AML cells from the bone marrow or blood survive poorly outside of the body, and AML cell lines carry many additional genetic and karyotypic abnormalities that make them distinct from primary tumors. Our new models are groundbreaking tools that can uniquely empower leukemia research.”