New study shows differing effects of obesity and metabolic syndrome on breast cancer
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A study conducted by the University of Oklahoma and published in the journal CANCER found that both obesity and metabolic syndrome-a cluster of conditions like high blood pressure and high blood sugar-increase the risk of breast cancer, but in differing ways for different subtypes of the cancer.
Breast cancer is one of the most prevalent cancers globally, significantly affecting women. It is the most common cancer among women, with millions of new cases diagnosed each year. According to the World Health Organization (WHO), breast cancer accounts for approximately 24.5% of all cancer cases in women, making it a leading cause of cancer-related deaths.
In the study, a total of 68,132 postmenopausal women without prior breast cancer and with normal mammograms were enrolled in the Women’s Health Initiative randomized clinical trials. The study population consisted of 63,330 women with an entry metabolic syndrome score. At the start, body mass index (BMI) was determined, and the metabolic syndrome score included the following criteria: (1) high waist circumference (≥88 cm), (2) high blood pressure (systolic ≥130 mm Hg and/or diastolic ≥85 mm Hg, or a history of hypertension), (3) a history of high cholesterol, and (4) a history of diabetes. The study outcomes included breast cancer incidence, breast cancer mortality, deaths following breast cancer, and results categorized by hormone receptor status.
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