Rare and missed cause of hereditary cancer
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2023-07-12 04:00 GMT | Update On 2023-07-12 04:00 GMT
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New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers. Their study concluded that the guidelines leave a significant number of patients undiagnosed.
In most cases of Lynch syndrome, mismatch repair deficiency is caused by an inherited mutation in a DNA mismatch repair gene. But mismatch repair deficiency can also be caused by something called methylation. This is a change to a gene called MLH1.
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