Study reveals, incorporating metastasis-directed radiation therapy enhances progression-free survival in patients with metastatic pancreatic cancer
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In a recent study published in the journal of clinical oncology, Researchers from The University of Texas MD Anderson Cancer Center demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy improves progression-free survival (PFS) in patients with oligometastatic pancreatic cancer. At a median follow-up of 17.3 months, PFS was 10.3 months in patients who received metastasis-directed therapy (MDT) plus chemotherapy compared to only 2.5 months in those who received standard chemotherapy treatment. Additionally, increased immune responses from MDT were connected to longer survival times.
Metastatic pancreatic cancer spreads rapidly to vital organs, posing significant challenges for disease management. Diagnosis often occurs at an advanced stage, reducing treatment efficacy and decreasing survival rates. The disease's complexity and resistance to many therapies also contributes to its poor prognosis. Chemotherapy, the main treatment option, generally offers a seven-month average survival time before disease progression.
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