What Makes Multiply Recurrent Meningiomas Most Aggressive Form of Brain Cancer? Study Finds
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Researchers at Baylor College of Medicine and Washington University School of Medicine in St. Louis have identified clinical and genetic predictors of multiply recurrent meningiomas (MRMs), a most aggressive form of this common brain tumor. Published in Science Advances, the study opens new opportunities for future development of potential biomarkers and therapeutic agents for these challenging tumors.
The team studied the tumors of 1,186 patients with primary meningiomas. Thirty-one of these primary tumors went on to be multiply recurrent meningiomas. The researchers compared clinical and genetic characteristics of multiply recurrent meningiomas with those of non-recurrent meningiomas (NRM). “We found that, compared to non recurrent meningiomas, multiply recurrent meningiomas are more numerous, larger and more common in men than in women,” said co-senior and co-corresponding author Dr. Akash J. Patel, associate professor of neurosurgery and member of the Dan L Duncan Comprehensive Cancer Center at Baylor.
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