New Research Highlights Effective Stem Cell Treatment for Inflammatory Eye Diseases
Advertisement
In a new study, researchers have proposed a novel therapy for ocular Graft-versus-host disease involving Mesenchymal stromal cells (MSCs). The team explored the potential of regenerative mesenchymal stem cells in reducing ocular inflammation in Graft-versus-host disease -infected mice. The study, published in The Ocular Surface, explores the potential of adipose-derived MSCs (adMSCs) to reduce inflammation and promote tissue repair.
Graft-versus-host disease (GVHD) is a common and severe complication that occurs after stem cell transplantation, where the donor’s immune cells attack the recipient’s tissues. Ocular manifestation of Graft-versus-host disease is among the most challenging to treat, often leading to chronic inflammation and corneal tissue damage, which can result in loss of vision.
Using mice that had been induced with chronic Graft-versus-host disease, researchers administered adipose-derived MSCs into the eyes via a single injection. Over three weeks, the researchers found that the adipose-derived MSCs treatment increased regulatory T cells while reducing inflammation in the mice. Further, adipose-derived MSCs -conditioned media enhanced cell migration and proliferation in laboratory scratch tests, showcasing the regenerative capacity of the cells. Importantly, the injected cells disappeared within a week, minimizing the risk of long-term complications such as tumor formation.
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.