Updated Guidelines for Standardization of Biochemical Indices for Bone Status
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The Joint International Osteoporosis Foundation (IOF) Working Group and the International Federation of Clinical Chemistry (IFCC) Committee on Bone Metabolism have published important updated guidelines for the correct use of biochemical indices of bone status. The guidelines are published in the journal clinical chemistry and laboratory medicine.
The newly proposed term, "Bone Status Indices" (BSIs), offers a comprehensive framework to unify terminology and improve comparability across studies. Unlike previously used terms such as "bone turnover markers" or "metabolic markers of bone turnover," which focus on isolated aspects of bone metabolism, Bone Status Indices provide a holistic representation of bone status and integrate a wider array of factors—including structural elements, metabolic byproducts, enzymes, and regulatory molecules.
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