Epilepsy and migraine drug causes birth defects

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-06-16 04:00 GMT | Update On 2022-06-16 08:55 GMT

Valproic acid-a well knowndrug used to treat epilepsy, migraine, and bipolar disorder-can cause birth defects when taken during pregnancy. Now, a study published in the journal PLOS Biology reveals one reason why. That being that valproic acid (VPA) puts some cells of the developing nervous system into senescence, a kind of halted state that keeps them from growing and dividing correctly.

In this new study, the researchers used Both human organoids-three-dimensional clusters of human cells grown in the lab-as well as mice to study embryonic exposure to VPA.

They discovered that VPA induces cellular senescence in neuroepithelial cells, the stem cells that give rise to the central nervous system.

Hence, the authors said that the work is one of the first to associate cellular senescence with developmental defects and overall, the discovery that atypical activation of senescence in the embryo can perturb development. This raises the intriguing possibility that it may also contribute to defects in developmental contexts beyond those that are studied.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Epilepsy and migraine drug causes birth defects

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