Harsh parenting can induce depressive symptoms later by hard-wiring changes into DNA

The researchers, from the University of Leuven in Belgium, selected 21 adolescents who reported good parenting (for example, the parents being supportive and giving the children autonomy), and compared them with 23 adolescents who reported harsh parenting (for example, manipulative behaviour, physical punishment, excessive strictness). All adolescents were between 12 and 16 years old, with a mean of 14 years for both groups. For both groups 11 adolescents were boys meaning that the two groups were comparable, with a similar age and a similar, boy-girl distribution. Many of those who had experienced harsh parenting showed initial, subclinical signs of depression.

The researchers then measured the range of methylation at more than 450,000 places in the DNA of each subject and found that this was significantly increased in those who reported a harsh upbringing. Methylation is a normal process which occurs when a small chemical molecule is added to the DNA, changing the way that the instructions written in your DNA are read: for example, methylation may increase or decrease the amount of an enzyme produced by a gene. Increased variation in methylation is known to be associated with depression. Evelien Van Assche said "We based our approach on prior research with identical twins. Two independent groups found that the twin diagnosed with major depression also had a higher range of DNA methylation for the majority of these hundreds of thousands of data points, as compared to the healthy twin".

Dr Van Assche (now working at the University of Munster, Germany) continued "The DNA remains the same, but these additional chemical groups affect how the instructions from the DNA are read. Those who reported harsher parenting showed a tendency towards depression, and we believe that this tendency has been baked into their DNA through increased variation in methylation. We are now seeing if we can close the loop by linking it to a later diagnosis of depression and perhaps use this increased methylation variation as a marker, to give advance warning of who might be at greater risk of developing depression as a result of their upbringing".

In this study we investigated the role of harsh parenting, but it's likely that any significant stress will lead to such changes in DNA methylation; so in general, stresses in childhood may lead to a general tendency to depression in later life by altering the way your DNA is read. However these results need to be confirmed in a larger sample".

Commenting, Professor Christiaan Vinkers, Department of Psychiatry, Amsterdam University Medical Centre, said:

"This is extremely important work to understand the mechanisms how adverse experiences during childhood have life-long consequences for both mental health and physical health. There is a lot to gain if we can understand who is at risk, but also why there are differing effects of strict parenting".

Ref:

E. Van Assche1, E. Vangeel2, K. Van Leeuwen3, H. Colpin4, K. Verschueren4, W. Van den Noortgate5, L. Goossens4, S. Claes2, Strict parenting may hard-wire depression risk into a child's DNA, EUROPEAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY MEETING, 35th Congress of the European College of Neuropsychopharmacology (ECNP)