No Major Birth Defects Linked to Paternal Metformin Use: Study
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A study published in the Annals of Internal Medicine found that paternal use of metformin monotherapy was not associated with major congenital malformations (MCMs) in newborns. Associations between metformin in polytherapy and birth defects could potentially be explained by the worse underlying parental cardiometabolic risk profile of those taking multiple diabetes medications.
Paternal use of metformin involves men taking the medication, often to manage type 2 diabetes, during the period of sperm production before conception. Metformin helps regulate blood sugar levels by reducing glucose production in the liver, improving insulin sensitivity, and decreasing sugar absorption in the intestines. While metformin is primarily used to treat diabetes, it has also been studied for other potential health benefits.
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