A single dose of magic mushroom Psychedelic can ease major depression: Study

In a randomized clinical trial with 104 participants, psilocybin treatment was associated with a clinically significant sustained reduction in depressive symptoms and functional disability, without serious adverse events. These findings add to increasing evidence that psilocybin—when administered with psychological support—may hold promise as a novel intervention for major depressive disorder.

Reference: Raison CL, Sanacora G, Woolley J, et al. Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. JAMA. Published online August 31, 2023. DOI: 10.1001/jama.2023.14530