TyG index closely associated with progression of depression

A recent study published in the Journal of Nutrition, Metabolism, and Cardiovascular Diseases found that baseline triglyceride glucose (TyG) index is closely associated with progression of depression. Also, from a metabolic perspective, TyG index monitoring requires more attention for mental health managements.

Cerebral symptoms are common among individuals with non-communicable conditions, while the longitudinal association between triglyceride glucose (TyG) index, indicator of metabolic health, and progression of depression remains unclear. So, this study by Lan Zheng and team aimed to check the association of birth TyG indicator and depression progression in middle-aged and elder grown-ups.

This retrospective cohort study was from the National China Health and Retirement Longitudinal Study and it included 8287 participants over 45 years out of which 45.9% were men.

The results showed that there was no significant difference of depression score at baseline across TyG quartile groups. Compared to those in the lowest, participants in the highest quartile of TyG index had a 0.124 higher change rate of depression score, and a 0.127 higher change slope.

The findings of this study strongly suggest that TyG index is positively associated with progression of depression specially in men, the elders and in obese people, this new insights might help in the primary prevention of depression.

Reference:

Zheng, L., Cui, C., Yue, S., Yan, H., Zhang, T., Ding, M., Sun, Q., He, C., & Ren, H. (2022). Longitudinal association between triglyceride glucose index and depression progression in middle-aged and elder adults: A national retrospective cohort study. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD. https://doi.org/10.1016/j.numecd.2022.11.015