High Spp1 Levels in Macrophages Link Environmental Pollution to Emphysema Development, Key Finding for COPD
Advertisement
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease characterized by airway obstruction and loss of alveolar surface, together resulting in progressive and irreversible airflow limitations and shortage of breath. Chronic bronchitis and emphysema are two major phenotypes of the disease. Cigarette smoke (CS) is a long-known cause of COPD, and it accounts for more than 70% of COPD cases, as reported by WHO,1 but the contribution of indoor and outdoor air pollution is increasingly acknowledged.
By analyzing multiple emphysema and COPD patient datasets, SPP1 is significantly upregulated in the lungs of patients, compared to healthy individuals. “These findings pointed out the clinical relevance of SPP1 induction during COPD development and has motivated us to understand their contributions in depth,” Dr. Lianyong Han, the lead author of the study says.
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.