Why Asthma Often Comes Back After Stopping Biologic Drugs? Study Sheds Light
While biological drugs have significantly improved the quality of life for individuals with severe asthma, a new study from the Karolinska Institutet suggests they may not completely eliminate the underlying immune cells that drive inflammation. Published in the journal Allergy, the research raises questions about the long-term effectiveness of these treatments and highlights the need for continued therapy in many cases.
Biologics, including medications like mepolizumab and dupilumab, are widely prescribed for patients with severe asthma and are known to control symptoms effectively. However, little has been understood about how these drugs interact with the immune system at a cellular level.
In the study, researchers analyzed blood samples from 40 patients before and during biologic treatment. Using advanced techniques like flow cytometry and single-cell sequencing, they discovered that some immune cells associated with high inflammatory potential, rather than decreasing, actually increased during treatment. These cells are known to contribute significantly to airway inflammation in asthma.
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