Bone biomarkers and prostate cancer survival strongly linked: Study

Written By : Isra Zaman

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2023-05-12 03:45 GMT | Update On 2024-05-13 11:29 GMT

Prostate cancer falls the top ten leading sites of occurrence for cancer in India. Understanding the factors that influence patient outcomes is critical for improving treatment and survival rates.

Research led by UC Davis Comprehensive Cancer Center reveals a link between bone metabolism biomarkers and survival in men with newly diagnosed hormone-sensitive prostate cancer (HSPC) who received androgen deprivation therapy (ADT). The work was published in European Urology.

The study analyzed results from a SWOG Cancer Research Network Phase 3 trial of nearly 1,000 patients on ADT, including some who were also on the novel hormonal therapy Orteronel. Patients participating in the trial came from 248 academic and community centers throughout the country.

Bone biomarkers for both bone loss and bone formation were measured in HSPC patients enrolled in the trial.

The researchers found that elevated bone biomarkers were associated with an increased risk of death. Bone biomarkers have been found to influence overall survival in men with castration-resistant prostate cancer (CRPC), but have not been fully established for HSPC. CRPC is a prostate cancer that continues to grow even when testosterone levels are greatly reduced.

Reference:

Bone biomarkers and subsequent survival in men with hormone-sensitive prostate cancer: Results from the SWOG S1216 Phase 3 trial of androgen deprivation therapy with or without Orteronel,European Urology, DOI 10.1016/j.eururo.2023.03.036

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Article Source : European Urology

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Isra Zaman

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

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Bone biomarkers and prostate cancer survival strongly linked: Study

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