Gut microbes differ in men with prostate cancer
Researchers have found a significant difference in the gut microbiota of men with prostate cancer, compared with those who have benign biopsies. The study is presented at the European Association of Urology annual congress (EAU2q2), in Amsterdam. Although the finding is an association, it could partly explain the relationship between lifestyle effects and geographical differences in prostate cancer.
The gut microbiota of 181 men who were suspected to have prostate cancer and undergoing prostate cancer diagnostics. The microbiota samples were collected at the time of their prostate biopsies after MRI scans.
Sixty percent of the men were diagnosed with prostate cancer, and their gut microbiota profiles were significantly different to those who had benign biopsies. The men with cancer had increased levels of Prevotella 9, members of the family Erysipelotrichaceae, and Escherichia-Shigella, a pathogen that causes diarrhoea. They also had lower levels of Jonquetella, Moryella, Anaeroglobus, Corynebacterium and CAG-352 than men without.
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