Case of drug induced syndrome of Inappropriate Antidiuretic Hormone reported
Use of selective serotonin reuptake inhibitors (SSRIs) has been reported to be associated with the syndrome of inappropriate antidiuretic hormone (SIADH), although it is uncommon. Nonsteroidal anti-inflammatory drugs (NSAIDs), as a sole agent, are an even rarer cause of SIADH. Despite being documented in the literature, the understanding of the mechanism of both agents is limited. Recently researchers have reported a case of a patient taking both of these medications, a dangerous combination that led to the development of SIADH.
In a recently published case report by Chia-Yu Chiu, from Department of Medicine, Lincoln Medical Center, Bronx, NY, USA ,in the American Journal Of Case Reports , an 88-year-old woman with a history of asymptomatic chronic hyponatremia presented to the facility with symptomatic acute-on-chronic hyponatremia after she started using naproxen in addition to her daily citalopram.
Her hyponatremia symptoms resolved after discontinuing these 2 offending agents, along with administration of fluid restriction and oral sodium supplements.
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