Medical Care for Adults with Down Syndrome: Guidelines by Global Down Syndrome Foundation
A working group for the Global Down Syndrome Foundation has issued the first evidence-based clinical practice guidelines on the medical care of adults with Down syndrome.The guidelines have been published in the Journal of American Medical Association.
Down syndrome is the most common chromosomal condition, and average life expectancy has increased substantially, from 25 years in 1983 to 60 years in 2020. Despite the unique clinical comorbidities among adults with Down syndrome, there are no clinical guidelines for the care of these patients.
To develop an evidence-based clinical practice guideline for adults with Down syndrome, the expert panel developed 10 Population/Intervention/ Comparison/ Outcome (PICO) questions addressing multiple clinical areas including mental health (2 questions), dementia, screening or treatment of diabetes, cardiovascular disease, obesity, osteoporosis, atlantoaxial instability, thyroid disease, and celiac disease.
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