Abdominal fat linked to widespread chronic pain, especially in women, reveals research

Published On 2024-09-10 23:30 GMT   |   Update On 2024-09-11 06:34 GMT
Advertisement

Excess abdominal fat is associated with widespread chronic pain, particularly in women, finds the first study of its kind, published in the open access journal Regional Anesthesia & Pain Medicine.

Reducing excess fat deposits in the abdomen may help reduce chronic musculoskeletal pain, especially if it’s experienced at multiple body sites, suggest the researchers.

Previously published research has shown that obesity is associated with musculoskeletal pain, but it’s not known if excess fat tissue is linked to chronic musculoskeletal pain and at multiple body sites, say the researchers.

Advertisement

To find out, they drew on data for 32,409 participants in the UK Biobank study who completed questionnaires and underwent health assessments. Around half (51%) were women, and their average age was 55.

They underwent MRI scans of their abdomen to measure the amount of fat around the abdominal organs (visceral adipose tissue or VAT) and the amount of fat just under the skin that can be pinched (subcutaneous adipose tissue or SAT).

When attending for their scan, participants were asked if they had experienced any pain in their neck/shoulder, back, hip, knee or ’all over the body’ for more than 3 months.

The MRI scan and pain assessments were repeated around 2 years later for 638 participants.

Comprehensive analyses showed a dose-response association between the number of chronic pain sites and VAT, SAT, the ratio of the two, and weight (BMI).

The association was stronger in women among whom the odds ratio of a higher number of chronic pain sites were twice as high for VAT, and 60% greater for both SAT and the VAT:SAT ratio. In men, these odds ratios were 34% 39%, and 13% higher, respectively.

Higher levels of fat tissue were also associated with greater odds of reporting chronic pain, and again the association was more pronounced in women.

All these associations remained even after adjusting for age, height, ethnicity, household income, educational attainment, alcohol intake, smoking status, physical activity, coexisting conditions, sleep duration, psychological problems and length of follow-up.

This is an observational study, and as such, can’t establish cause and effect, and the authors also acknowledge various limitations.

These include the relatively small size of the repeat imaging sample, and the absence of an assessment of severity in the pain questionnaire. More follow-up visits would also have allowed more information to be gathered on patterns and fluctuations in the number of chronic pain sites, they add.

But they conclude: “Abdominal adipose tissue was associated with chronic musculoskeletal pain, suggesting that excessive and ectopic fat depositions may be involved in the pathogenesis of multisite and widespread chronic musculoskeletal pain.”

They add: “Therefore, reducing abdominal adiposity may be considered a target for chronic pain management, particularly in those with pain in multiple sites and widespread pain.”

And they suggest that the stronger associations seen in women may be a consequence of sex differences in fat distribution and hormones.

Reference:

Kifle ZD, Tian J, Aitken D, et alMRI-derived abdominal adipose tissue is associated with multisite and widespread chronic painRegional Anesthesia & Pain Medicine Published Online First: 10 September 2024. doi: 10.1136/rapm-2024-105535.

Tags:    
Article Source : Regional Anesthesia & Pain Medicine

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News