Almost all severely allergic people could complete 2 dose COVID vaccine protocol: JAMA

"The results of this study can help guide expectations for patients with high-risk allergy histories. Symptoms such as hives and swelling may occur, particularly with the first vaccine dose, but most reported allergic symptoms did not impede completion of the two-dose mRNA vaccine series," says lead author Lily Li, MD, allergy faculty in the Division of Allergy and Clinical Immunology at Brigham and Women's Hospital.

The findings provide reassurance regarding the safety of mRNA COVID-19 vaccination in individuals regardless of allergy history. "We hope these data will help inform ongoing conversations with patients who are hesitant to receive COVID-19 vaccination due to allergy concerns," says senior author author Kimberly G. Blumenthal, MD, MSc, co-director of the Clinical Epidemiology Program within Massachusetts General Hospital's Division of Rheumatology, Allergy and Immunology. "At our institutions, nearly all individuals with and without a history of high-risk allergy were able to complete the two-dose vaccine series."