Recent research, published in Science Advances has found that exercise-induced H1/H2 receptor signaling is essential for the integrative beneficial effects of exercise training on exercise capacity, metabolic control, and vascular function. The findings further confirm that anti histamines may suppress the benefits of exercise.Exercise training is a powerful strategy to prevent and...
Recent research, published in Science Advances has found that exercise-induced H1/H2 receptor signaling is essential for the integrative beneficial effects of exercise training on exercise capacity, metabolic control, and vascular function. The findings further confirm that anti histamines may suppress the benefits of exercise.
Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood.
In recent years, histamine has emerged as a potentially important mediator of acute and chronic exercise responses . The primordial basis of the histamine system dates back from before the origin of multicellular organisms, with a highly conserved genetic sequence of the histamine-forming enzyme histidine decarboxylase, which also is present in humans . Histamine exerts its biological effects via four heterotrimeric guanine nucleotide-binding protein–coupled histamine receptors, H1 to H4, of which H1 and H2 receptors are most frequently studied in relation to exercise and are known to be widely expressed within skeletal muscle. It is currently unknown whether and how the histamine system is relevant for exercise training adaptations.
The recent study highlighted that chronic blockade of histamine H1/H2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H1/H2 receptors were pharmaceutically blocked.
Highlights from the findings are summerised below.
Post-exercise muscle perfusion is dependent on H1/H2 receptor signaling.
· Exercise capacity and mitochondrial function are regulated by H1/H2 receptors.
· Improvement in whole-body glucose homeostasis is blunted by H1/H2 blockade.
· Blunted training-induced improvement in NO-dependent vascular function and muscle capillarization with H1/H2 blockade.
· H1/H2 receptor–dependent adaptations to interval training are highly interrelated.
"Our work suggests that histamine H1/H2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept."the team has concluded.
For full article follow the link: DOI: 10.1126/sciadv.abf2856
Primary source:Science Advances
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