Asthma and COPD highly associated with SLE patients, Finds study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-04-27 02:00 GMT | Update On 2021-04-27 02:34 GMT

Recent research stated that there is an increase in evidence of the prevalence of asthma and COPD in individuals with systemic lupus erythematosus (SLE), according to the study published in the American College of Rheumatology.

SLE is associated with significant decrements in patient‐reported outcomes (PROs), such as physical function and fatigue as well as overall quality of life. Asthma and COPD each have also been demonstrated to have significant impacts on PROs.

Despite the potential increased risk of both asthma and COPD in SLE, and the demonstrated impact of both conditions on PROs, little research has focused on the impact of asthma or COPD on outcomes in SLE.

Hence, Patricia Katz and colleagues from the University of California San Francisco, San Francisco, California carried out the present study to examine the prevalence, incidence, and impact of self‐reported asthma and COPD in two US‐based SLE cohorts (FORWARD and Lupus Outcomes Study [LOS]).

Prevalence of asthma and COPD were defined as presence of conditions at individuals' first interviews; incidence was defined as new reports over the next 3 years. Cross‐sectional associations of asthma/COPD with patient‐reported outcomes (PROs) and longitudinal analyses associations with asthma/COPD at entry with PROs 3 years later were examined.

The key findings highlighted in the study were-

19.8% and 8.3% participants reported asthma and COPD, respectively, at entry.
In LOS, 36.0% reported the presence of either (US population comparisons: asthma, 9.7%; COPD, 6.1%).
Cross‐sectionally, asthma/COPD was associated with worse PROs, including disease activity.
Individuals with asthma experienced greater worsening of fatigue, pain, and global health ratings longitudinally; individuals with COPD experienced greater increases in self‐reported SLE activity.

However, no such patterns were noted in the LOS.

Therefore, the authors concluded that "asthma and COPD appeared to be more common in SLE than in the general US population and were associated with worse status on PROs cross‐sectionally. Asthma was linked to decrements in PROs longitudinally."

Article Source : American College of Rheumatology

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Asthma and COPD highly associated with SLE patients, Finds study

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