Clinical Logic Deficit: IJMM Study Compared UTI and RTI Antibiotic Prescribing Trends

While Antimicrobial Resistance (AMR) is a top global threat projected to cause 10 million annual deaths by 2050, previous research indicates that up to 50% of prescriptions are irrational, creating a clinical gap in community-level data that prompted Vinay Modgil and his colleagues from the Postgraduate Institute of Medical Education and Research (PGIMER) to evaluate local antibiotic patterns and rationality to optimize care.

Therefore, the cross-sectional research examined a substantial sample of 1,219 outpatient antibiotic prescriptions over a twelve-month period from August 2021 to August 2022 at a 30-bed community health center serving a population of 12,900, where infectious disease specialists and clinical pharmacologists assessed primary endpoints of adherence to the Essential Drug List (EDL) and prescription logic based on National Centre for Disease Control (NCDC) and World Health Organization (WHO) standards.

Key Findings of the Study Include:

• Dominant Prescription Trends: The study identified amoxicillin and clavulanic acid as the most frequently utilized antibiotic, representing 27.2% of the total prescriptions, followed by metronidazole at 13.4% and azithromycin at 10.3%.

• Rationality Discrepancies: The study emphasized a significant rationality gap in common ailments, finding that only 29% of RTI cases were treated logically, whereas UTI saw a higher justification rate of 57%.

• WHO AWaRe Distribution: The study noted that 49.7% of antibiotics belonged to the "Access" group and 27.3% to the "Watch" group, highlighting that the 60% national "Access" group consumption target set by the World Health Organization has yet to be met in this setting.

• Target Demographics: The study revealed that adults between 20 and 40 years of age were the primary recipients of antibiotic therapy, accounting for 30.9% of the cohort, followed by the pediatric group aged 0 to 10 years at 20.4%.

• Common Clinical Diagnoses: The study observed that diarrhea and respiratory tract infections were the primary diagnoses associated with unnecessary antibiotic use, marking them as key targets for future antimicrobial stewardship efforts.

The results suggest that targeted interventions are necessary to reduce superfluous antibiotic consumption in conditions like diarrhea and respiratory tract infections, particularly given that the study found 54% of all antibiotic recipients were female.

This study concludes that clinicians should strive for stricter compliance with established evidence-based protocols and participate in specialized educational programs to ensure the long-term efficacy of available antimicrobials.

Although the single-center evaluation offers vital insights into local public health practices, additional multicentric research is needed to better understand broader prescribing trends and refine antimicrobial stewardship strategies across different regions.

Reference

Modgil V, Shafiq N, Gondara A, et al. An evaluation of antibiotic prescription pattern and drug rationality analysis among outpatients at public health setting, India. Indian J Med Microbiol. 2025;55:100829. doi:10.1016/j.ijmmb.2025.100829.