Colchicine reduces knee and hip replacement in osteoarthritis patients
A 0.5 mg daily dose of colchicine was related with a decreased incidence of total knee replacements (TKRs) and total hip replacements (THRs) in an exploratory analysis of the LoDoCo2 (Low-Dose Colchicine 2) study, says an article published in Annals of Internal Medicine.
Osteoarthritis is a leading cause of pain and disability globally. Anti-inflammatory medicines may decrease disease progression since inflammation has a role in the development of osteoarthritis. As a result, Michelle Heijman and colleagues undertook this trial to see if taking 0.5 mg of colchicine daily lowers the number of total knee and total hip replacements.
The LoDoCo2 (Low-Dose Colchicine 2) controlled, randomized, double-blind experiment from 43 centers in Australia and the Netherlands was examined in this exploratory study. This study included 5522 individuals with persistent coronary artery disease.
The exposure medium was 0.5 mg colchicine or placebo once daily. The primary outcome was the time since randomization to the first TKR or THR. All analyses were conducted with the intent-to-treat principle in mind.
The key findings of this study were:
During a median follow-up of 28.6 months, 2762 individuals took colchicine and 2760 received a placebo.
In the experiment, 68 patients (2.5% in the colchicine group) and 97 (3.5% in the placebo group) had TKR or THR.
Similar results were observed in sensitivity analyses when baseline gout patients were eliminated as well as when joint replacements that took place in the first three and six months of follow-up were not included.
The results of this study provide preliminary evidence that low-dose colchicine may reduce the course of osteoarthritis, but they also noted that this has to be validated in a prospective, placebo-controlled study that is well planned.
Reference:
Heijman, M. W. J., Fiolet, A. T. L., Mosterd, A., Tijssen, J. G. P., van den Bemt, B. J. F., Schut, A., Eikelboom, J. W., Thompson, P. L., van den Ende, C. H. M., Nidorf, S. M., Popa, C. D., & Cornel, J. H. (2023). Association of Low-Dose Colchicine With Incidence of Knee and Hip Replacements. In Annals of Internal Medicine. American College of Physicians. https://doi.org/10.7326/m23-0289
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