5mg Dapagliflozin every day attenuates CV events among diabetes patients with chronic HF

The results showed that 87.7% of patients in the dapagliflozin group received 5 mg at the end of the 2-year observation period. Although dapagliflozin did not reduce urinary albumin excretion, the primary endpoint, the secondary endpoint of cardiovascular events (cardiovascular death or hospitalisation for cardiovascular events and additional heart failure medication) was reduced in the dapagliflozin group compared to the standard treatment group.

This is the first report that dapagliflozin administration centered on 5 mg suppressed cardiovascular events in patients with chronic heart failure and type 2 diabetes mellitus. The results of this study are expected to provide valuable insight into treatment strategies for patients with type 2 diabetes mellitus and chronic heart failure. They are expected to make a significant contribution to clinical practice.

Reference:

Fumiki Yoshihara ab, Miki Imazu ab, Ichiro Sakuma, Yukio Hiroi, Hisao Hara, Osamu Okazaki, DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, parallel-group, standard treatment-controlled trial, DOI:https://doi.org/10.1016/j.eclinm.2023.102334.