Early DAPT initiation may prevent stroke recurrence in Mild Stroke and High-Risk TIA Patients: NEJM
In a groundbreaking clinical trial spanning 222 hospitals across China, researchers have discovered a potentially game-changing treatment for individuals with mild ischemic stroke or high-risk transient ischemic attack (TIA) of presumed atherosclerotic origin. The trial found that among patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause, combined clopidogrel–aspirin therapy initiated within 72 hours after stroke onset was associated with a lower risk of new stroke at 90 days compared to aspirin therapy alone.
The trial results were published in the journal The New England Journal of Medicine.
Initiating dual antiplatelet treatment within the first 24 hours following an acute mild stroke has demonstrated a reduction in the risk of recurrent stroke compared to aspirin alone. However, there is limited research on the comparative effects of clopidogrel plus aspirin versus aspirin when administered within 72 hours after acute cerebral ischemia resulting from atherosclerosis. Hence, researchers conducted a double-blind, randomized, placebo-controlled, two-by-two factorial trial to evaluate the effect of dual antiplatelet therapy on acute cerebral ischemia within 72 hours after the onset.
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