Faster Sodium Correction Linked to Lower Mortality in Severe Hyponatremia: Study
Researchers have found in a new study that among hospitalized adults with severe hyponatremia, medium or fast sodium correction was associated with a lower risk of death and delayed neurologic complications compared with slow correction. Although causality was not established, the findings suggest that current treatment guidelines for severe hyponatremia may need reevaluation and revision.
Slow correction of severe hyponatremia is recommended to prevent osmotic demyelination syndrome but is associated with higher mortality. A study was done to examine the association between sodium correction rates and death or delayed neurologic events. It was a retrospective cohort study. The primary outcome was a composite of 90-day death or delayed neurologic events (new demyelination, paralysis, epilepsy, or altered consciousness between 3 and 90 days from admission). Standardized risk differences (RDs) were generated using targeted maximum likelihood estimation. Heterogeneity of effect was assessed across grades of predicted risk.
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