Fecal microbiota transplants improve diarrhoea in majority patients with C. diff

The Researchers at the University of Birmingham have found that Faecal Microbiota Transplants (FMT) are highly successful in treating patients with Clostridioides difficile (C.diff) infection. The results of the study have shown that in 78% of cases the patient's diarrhoea had stopped and had not returned in the 90 days after treatment. The study has been published in EClinical Medicine.

Antibiotics can be effective in treating the first episode of C.diff. However, 10-20% of patients don't respond and the infection then recurs. Success rates of antibiotics in relapsing infection can be as low as 30%.

C.diff infections result from the good gut bacteria being killed by antibiotics given for other infections and cause severe diarrhoea, abdominal pain and may be fatal in elderly patients.

During FMT, the good bacteria in the faeces of a healthy donor are transferred to the gut of a patient with the infection.

The Microbiome Treatment Centre at the University of Birmingham is the first in the UK to be licensed for FMT preparation by the Medicines and Healthcare products Regulatory Agency (MHRA), supplying NHS patients across the country.

Before the dedicated centre was set up, many patients across the UK were unable to access this treatment.

Scientific studies have demonstrated that FMT treatment is better than treatment with special expensive antibiotics for C.diff infections, particularly when the patient's infection has come back again.

The development of a licensed FMT service at the University of Birmingham will widen the supply and improve equality of access to FMT treatment across the NHS. It will provide critical support for researchers both here in Birmingham and in other centres working on how FMT produces a cure not only in C.diff infection but also conditions such as ulcerative colitis and other diseases that seem to be linked to the gut microbiome.

Lead author Dr Victoria McCune, Consultant Clinical Scientist in Microbiology at South Tees Hospital NHS Foundation Trust, said:

"Our research has successfully shown the benefits of treating recurrent C.diff patients with FMT. Our standardized approach to making FMT will improve the quality and safety of this treatment for many more patients."

Professor Peter Hawkey, Professor of Clinical and Public Health Bacteriology at the University of Birmingham's Institute of Microbiology and Infection, said:

"This work has turned an unregulated potentially dangerous method of faecal transplantation into a national service providing rapid, safe regulated, life-saving treatment for a serious disease affecting thousands of patients in the UK."