Fremanezumab helps prevent chronic migraine and improve QOL, claims study

Results put forth some key facts.

• For the 219/1121 (19.5%) patients with moderate to severe depression at baseline, fremanezumab was associated with a significant reduction in monthly number of headache days of at least moderate severity for active treatment versus placebo (least-squares mean change ± standard error for quarterly dosing: −5.3 ± 0.77; for monthly dosing: −5.5 ± 0.72; and for placebo: −2.2 ± 0.81; both p < 0.001).
• More patients achieved a ≥50% reduction in headache days of at least moderate severity with fremanezumab (quarterly: 31/78 [39.7%]; monthly: 39/96 [40.6%]) than placebo (9/67 [13.4%]; both p < 0.001).
• Compared with placebo, fremanezumab improved PGIC and HIT-6 scores.

" Fremanezumab demonstrated a significant treatment benefit over placebo in reducing the monthly average number of headache days of at least moderate severity and migraine days in patients with CM and comorbid moderate to severe depression. Greater improvements in HRQoL, headache impact, and patient-reported overall health status were also seen with fremanezumab than with placebo. Fremanezumab may benefit patients with migraine and comorbid depression by reducing the frequency of migraine and headache days, decreasing disability, and improving HRQoL."the team opined.

For full article follow the link: https://doi.org/10.1111/head.14097

Source: Headache