Herbal Medicine Schisanhenol: A potential drug for treatment of cytokine storm

SSH significantly inhibited NF-κB pathway activity and suppressed macrophage and systemic inflammatory responses in mice. SSH also effectively alleviated lipopolysaccharide-induced acute lung injury. The network pharmacology results showed that estimated glomerular filtration rate, matrix metalloproteinase 9, proto-oncogene tyrosine-protein kinase Src, and mammalian target of rapamycin are potential key target proteins of SSH.

The findings of this study demonstrate that SSH inhibited the macrophage inflammatory response and cytokine production at both the systemic and local levels in mice. Additionally, SSH effectively mitigated acute lung injury resulting from CS. Furthermore, network pharmacological analysis revealed that SSH has the ability to suppress inflammatory response through multiple mechanisms.

Reference:

Wenjun Qi, Dandan Shi, Ruojia Zhang, Xuehong Lin, Mengxue Lü1, Yuang Zhang, Jihong Pan, Wei Chen, Luna Ge, and Lin Wang, Schisanhenol: A Potential Drug for the Treatment of Cytokine Storm, Exploratory Research and Hypothesis in Medicine, doi: 10.14218/ERHM.2023.00054.