Higher serum uric acid linked to VTE recurrence

Key findings of the study include:

• Patients were stratified according to SUA tertiles distribution at baseline (tertiles cut‐off: I ≤ 4.37 mg/dl, II 4.38 – 5.54 mg/dl, III ≥ 5.55 mg/dl).
• Fifty episodes of VTE recurrence occurred during the follow‐up and Kaplan‐Meyer survival analysis showed that subjects in the lower tertile of SUA distribution had significant lower risk of future VTE recurrence.
• No difference were seen among patients belonging to the second and the third tertile of SUA distribution.
• A multivariate Cox regression analysis showed that higher tertiles of SUA distribution had about 3‐fold increase in the risk of VTE recurrence as compared to subjects with SUA ≤ 4.37, independently from potential confounders (HR 3.04).
• The adjusted hazard of VTE recurrence increases by 30% for each additional unit of SUA (mg/dl) (HR 1.30).